The United States Postal Service employed highway post offices (HPO) in the back of large buses as a means of sorting mail between offices, mostly in remote areas. The first run of the HPO was from Washington, DC to Harrisburg, VA on February 10, 1941. The HPO were designed to replace Rail Post Offices (RPO) with declining rail traffic. Postal service was reorganized with Post Office Sectional Sorting Centers reducing the need for sorting mail enroute in the early 1970s. The last Highway Post Office run was made on June 30, 1974, although there was a first run reenactment in 1988.

US #974 on HPO between Utica, Oneonta, & Binghamton, NY

US #974 on HPO from Coffeyville to Wichita, KS

US #995 on HPO from Florence, SC to Fayetteville, NC

US #1145 on HPO from Milwaukee to Green Bay, WI